What's wrong ( with you) ?What's the matter (with you ) ? What's your problem? What's your complaint? What's your trouble ? What's up ? 括号中的可以省略。另外complaint在这是"疾病"之意。 祝您学习进步。
1 如果只是表示关切：Anything wrong with you?2 如果要确切地知道是"哪儿"不舒服：Where do you feel not well?
Where is the spot you feel most uncomfortable?
What’s wrong with you?What's the matter?上面两个都可以的~三楼的，你开玩笑，你那是Chinese English~
What's wrong with you?
You are not comfortable there?
The doctor asks patient about it:（医生问病人）You are unwell somewhere?(你哪里不舒服?)
what's wrong with you?和what's the matter? 都可以的
What's bothering you? Have you got a pain in…？
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北京美克
